ANTI-HYPERGLYCAEMIC EFFECT OF ETHANOL EXTRACT OF Bridelia ferruginea LEAVES ON ALLOXAN-INDUCED ..

The aim of this study was to see whether an ethanol extract of Bridelia ferruginea leaves could prevent alloxan-induced diabetes in male albino rats. Methodology: Bridelia ferruginea leaves were extracted with ethanol. Normal methods were used for phytochemical screening, acute toxicity tests, lipid profile determination, and antidiabetic studies. All groups except group 1 (normal control) were given 120 mg/kgof 1% alloxan monohydrate intraperitoneally to induce diabetes. The animals were divided into six groups of five animals each and given the following treatment: Groups 1 and 2 were given 0.5 ml/kg of 0.9 percent normal saline, group 3 was given 5 mg/kg of glibenclamide (a common drug), and groups 4, 5, and 6 were given 100, 200, and 400 (mg/kg) of the extract, respectively. Results: Alkaloids, flavonoids, saponins, tannins, glycosides, terpenoids, reducing sugar, sugars, hydrogen cyanide, phenols, and steroids were found in varying amounts in phytochemical screening. (EEBFL) was found to be safe up to 5000 mg/kg body weight in an acute toxicity analysis. In comparison to the untreated diabetic control, rats treated with graded doses of ethanol extract of Bridelia ferruginea leaves showed a substantial (p 0.05) reduction in blood glucose levels. The gap between group 5 and the standard control was not important. The total cholesterol, LDL cholesterol, and HDL cholesterol levels all decreased significantly (p 0.05) in the lipid profile.When compared to untreated diabetic controls, the treated groups had significantly higher levels of HDL and triacylglycerol, as well as a substantial rise in HDL. Conclusion: The results of this study showed that an ethanol extract of Bridelia ferruginea leaves has strong antihyperglycaemic and antihyperlipidemic properties and can be used as a herbal remedy to treat diabetes and its complications.

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