DEVELOPMENT AND VALIDATION OF A METHOD FOR THE DETERMINATION OF MOEXIPRIL IN PHARMACEUTICAL .....

A new, easy, and sensitive spectrophotometric approach for determining the antihypertensive medication moexiprilHCl (MOXL) in tablets has been developed and confirmed. The method is based on the production of complexes between MOXL and various metal ions such as Cu2+ and Zn2+ in a borate buffer with pH 10.3 for Cu2+ (Procedure A) and 10.5 for Zn2+ (Procedure B) (Procedure B). For both Cu2+ and Zn2+, the absorbance of the generated complex is measured at 282 nm. In the concentration ranges of 5-98 and 5-85g ml-1 for Cu2+ and Zn2+ complexes, respectively, Beer's law is obeyed with a good correlation coefficient (0.9999). The molar ratios of the metal complexes are determined, and a chemical pathway is proposed as a result. The proposed approach was validated in accordance with ICH guidelines and was successfully used to determine MOXL in tablet dose forms.

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