EFFECT OF THE ORGANOPHOSPHORUS INSECTICIDE RAIDER® (CHLORPYRIPHOS 20% EC) ON METABOLITES

The effect of the organophosphorus pesticide Raider® (chlorpyriphos 20 percent EC) on metabolites in the New Zealand Rabbit's (Oryctolagus cuniculus) brain was studied. This was done to see what the consequences of using pesticides in soils and foliage to control insects would be, as well as the detrimental impacts on human and animal health. The study used a total of eighteen (18) healthy adult male New Zealand Rabbits weighing between 1.8 and 2.0kg that were purchased from a local market. The rabbits were acclimated for two weeks before being fed ad libitum with synthetic grower's marsh pellets and 1.5L tap water. During the acclimatisation period, no one died. One control group and three (3) treatment levels were separated into four (4) groups of rabbits. There were three (3) replicates in each group. The toxicant was diluted in 1.5L of water and given to the Rabbits in each compartment at concentrations of 1ppm, 2ppm, and 3ppm based on the range finder test. There was no toxicant added to the 1.5L of water in the control group. Rabbits were given the toxicant for 14 days before being slaughtered with a surgical knife and restraint. The Rabbit's brain was dissected and transported to the Niger Delta University Teaching Hospital's laboratory for examination of the metabolites total glyceride (TG), total creatinine (TC), total protein (TP), and cortisol using conventional techniques. The means and standard deviations of the data were calculated. At the 95 percent confidence level, analysis of variance (ANOVA) was used to examine the variability and similarity in the observed parameters between treatment groups. To distinguish means, the turkey HSD Post HOC test was used. The SPSS 20.0 tool kit was used to do this. TG degraded considerably from 0.89 mmol/L at control (0ppm) to 0.55 mmol/L at 3ppm, according to the findings. At 3ppm, TC dropped from 2.83nmol/L at 0ppm to 1.05nmol/L. TP levels also fell from 6.93g/L at 0ppm to 4.81g/L at 3.0ppm, while cortisol levels rose from 62.83mmol/L at 0ppm to 77.97mmol/L at 3ppm. Between control and all treatment doses, there were significant variations in TC, TP, and cortisol (P0.05). There was a significant difference (P0.05) between the control and 3ppm treatment levels, but no significant change (P>0.05) between the control and 1ppm and 2ppm treatment levels. The findings imply that the insecticide is poisonous and hazardous to the brains of animals exposed to it. As a result, it should be used with caution and restraint.

Please see the link :- https://www.ikprress.org/index.php/JOGEE/article/view/6399