In-vitro ANTIFUNGAL STUDY OF CRUDE EXTRACT OF Barringtonia asiatica (L.) Kurtz AGAINST FUNGAL PATHOG

Introduction: Barringtonia asiatica (L.) Kurtz is a plant native to tropical mangrove ecosystems and belongs to the Lecythidaceae family. The goal of this study was to see how effective a crude extract of Barringtonia asiatica (L.) Kurtz was against fungal pathogenic strains in vitro.

Materials and Methods: In order of increasing polarity, extractions were carried out using the traditional method of cold-soaking in non-polar, medium polar, and polar solvents (hexane, dichloromethane, chloroform, ethyl acetate and methanol). The antifungal activity of Candida tropicalis, Fusarium oxysporum, Aspergillus niger, and Aspergillus flavin was assessed using a disc diffusion assay with Potato dextrose agar medium (PDA), Diflucan as a control and Candida tropicalis, Fusarium oxysporum, Aspergillus niger, and Aspergillus flavin as pathogens.

Results: At 500 g/mL, hexane extract inhibited Aspergillus niger significantly, with an inhibition zone of 14.770.05 mm. With an inhibition zone of 15.93 0.05 mm, dichloromethane crude leaf extract inhibited Fusarium oxysporium growth more effectively.

Conclusion: The goal of this work is to show that Barringtonia asiatica may be used in a variety of solvents, including non-polar and polar crude extracts, to battle antifungal resistance and diseases resistant to contemporary medicine.

Please see the link :- https://www.ikprress.org/index.php/AJMAB/article/view/5091