RAMAN SPECTROSCOPIC AND POTENTIOMETRIC STUDIES OF ACIDITY LEVEL AND DISSOCIATION OF CITRIC ACID IN..

The dissociation constant is one of the most significant properties of a pharmaceutical chemical moiety that must be accurately determined. The development of in-situ speciation methods in solutions with parallel measurements using Raman spectroscopy (molecular) and pH (macroscopic) for the identification, characterization, and quantitative determination of citric acid species in aqueous solution using a multiwavelength curve fitting programme over a pH range is described. As a result, citric acid's first, second, and third stepwise dissociation constants have been calculated to be 3.020.06, 4.780.06, and 6.020.04, respectively. An excellent agreement with literature values was obtained from these data over the pH range 2.38-6.16.

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