SYNTHESIS, CHARACTERIZATION AND BIOACTIVITY OF TRANSITION METAL COMPLEXES WITH CARBOXYAMIDE ......

Physico-chemical approaches have been used to produce and analyse the carboxyamide ligand N,N'-bis(3-hydroxybenzoyl)pyridine-2,6-diamine and its Co(II), Ni(II), and Cu(II) complexes. Deprotonation of the OH group and coordination of the ligand's amide carbonyl are shown by vibrational spectra. The mass spectrum explains and supports ML complexes by explaining the sequential destruction of molecular species in solution. The Cu(II) complex has an epr of gâ€â€ g> 2.03, indicating that unpaired electrons are most likely in the dx2-y2 (or less likely a dxy) ground state, which is consistent with the proposed square based geometry. The square planar structure of metal complexes is revealed through electronic spectra and magnetic susceptibility measurements. The cell characteristics of the complexes can be determined using X-ray powder diffraction data. The complexes' molecular structure has been optimised using MM+ computations, and it supports a square planar shape. The bio-efficacy of the ligand and its metal complexes was tested in vitro against bacterial growth to determine their antimicrobial potential.

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