SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL STUDIES OF N-METHYLINDOLE-3-THIOACETIC ACID | Journal...

The goal of the research was to create molecules having biological properties. By reacting N-methyl indole with potassium iodide/iodine mixture followed by addition of thiourea, N-methylindole-3-isothiouronium iodide was produced in two steps but one pot reaction. N-methylindole-3-thioacetic acid was produced in a two-step, one-pot procedure by hydrolyzing N-methylindole-3-isothiouronium iodide in a 10% sodium hydroxide solution under hydrogen atmosphere. Monochloroacetic acid was used to treat the reaction mixture. A Fourier Transform infrared spectrophotometer (FT-IR), nuclear magnetic resonance (1D and 2D NMR), and electro-spray ionisation mass spectrometer were used to determine the structures of the substances (ESI-MS). At a concentration of 10 mg/L, the produced compounds were tested for antibacterial activity. The antibacterial screening findings revealed that the compounds had some antibacterial action against the test microorganisms. The test weeds (Eleusine indica, Sporobolus pyramidalis, Tridax procumbens, and Ageratum conyzoides) were subjected to a five-week herbicidal bioassay using N-methylindole-3-thioacetic acid at various dosages (0.5, 1.0, 1.5, 2.0, and 2.5 g/L), with 2, 4-D (2, 4-dichlorophenoxyl acetic acid) as The results showed that the produced chemical had no herbicidal action. However, the finding revealed that the molecule may have plant growth-regulating properties, although more research is needed to confirm this.

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