SYNTHESIS, CHARACTERIZATION, ANTIMICROBIAL, AND ANTIOXIDANT STUDIES OF NEW-FANGLED M(II) COMPLEXE...

Aims: The purpose of this study is to characterise a new imine-chelator and its Fe2+, Ni2+, and Cu2+ chelates produced from 2-hydroxyl-1-naphthaldehyde and 2-amino-4-methylphenol, as well as to assess its bactericidal, antifungiform, antioxidant, and extractive potentials.

Materials and Methods: The synthesised chelator and its chelates were studied using spectral (UV/visible, vibrational, and nuclear magnetic resonance) methods, analytical (C, H, N, Melting point, magnetic susceptibility, and conductance, complexometric) techniques, and biological (antimicrobial, antioxidant, and extractive potentials) appraisals.

Results: A novel heterocyclic chelator, 3-[(2-hydroxy-5-methylphenylimino)-methyl]-napthalen-2-ol, as well as its Fe2+, Ni2+, and Cu2+ chelates, was synthesised and characterised using proton nuclear magnetic resonance (1H NMR), vibrational (FT-IR), mass (ESI-MS), and electronic spectral techniques, as well as micro (C,H,N) analysis, magnetic suscept The FT-IR spectral values obtained indicated that the chelator had excellent chelation properties towards the 3d-M2+ ions due to the deprotonated oxygen and imine nitrogen atoms. Experimental data from C,H,N-analysis, eff, and electronic spectral evaluations were used to deduce the structural assemblages leading to the geometries (octahedral, square planar, and tetrahedral for Fe2+, Cu2+, and Ni2+ chelates). The 1H NMR and ESI-MS readings, in addition to the latter, formed the basis for the chelator's hypothesised structure. The chelates' neutrality was confirmed by molar conductance data. The ESI-MS spectrum revealed credible fragmentation paths, stoichiometric contents, and the chelator's formula weight. The compounds' antibacterial activities against isolated microbial strains were changed in vitro.

Conclusion: The [Fe(C36H32N2O6)] exhibited superior antibacterial activity against all microorganisms tested, with inhibited growth zones comparable to the conventional medicines. The compounds had good DPPH antioxidant scavenging properties, with the [Ni(C36H30N2O5)] chelate having the best antioxidant activity, with an IC50 of 98 percent, an IC100 of 99 percent, and an IC200 of 99 percent when compared to the others.

Please see the link :- https://www.ikprress.org/index.php/JACSI/article/view/7189