UTILITY OF 4-aryl-8-arylidene - 3, 4, 5, 6, 7, 8-hexahydroquinazoline-2-thiol FOR THE SYNTHESIS OF..

The synthesis and reactions of 4-aryl-8-arylidene-3,4,5,6,7,8-hexahydroquinazoline-2-thiol 1a-c are the focus of this research. Hexahydroquinazolinyl hydrazine was obtained via hydrazinolysis of chemical 1a. 2. A [1,2,4] triazolo[3,4-b] quinazoline derivative was obtained by acetylation of compound 2. 3. Hexahydroquinazolin-2-yl-hydrazinyl-2-oxoacetate 9 and hexahydroquinazolin-2-yl-3-oxobutane hydrazide were obtained by reacting compound 2 with diethyl oxalate and ethyl acetoacetate. 10. Compound 1 was treated with chloroacetyl chloride to produce tetrahydro-2H-thiazolo [2, 3-b] quinazolin-3(5H)-one 13, which was utilised as a starting point for a series of heterocyclic compounds (14-19). On the basis of elemental analyses and spectrum data, the structures of the produced compounds were deduced. Some newly synthesised substances were tested for antioxidant activity. Using the DPPH technique, compounds 2, 3, 12, 13, 15, 16, and 19 demonstrated antioxidant activity.

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